ADVANCED PERIODONTAL SALIVA TESTING FOR DENTAL PRACTICES

Stop Guessing. 

Start Testing.

Know the your patient's pathogen profile. Support informed care.
UniquePerioSignature™ uses saliva-based qPCR technology to detect and quantify five targeted periodontal pathogens from a simple saliva sample. Receive quantitative results in as little as 2 business days to support clinical assessment and patient management.
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DIRECT-TO-CONSUMER PERIODONTAL SALIVA TESTING

Know Your Periodontal 

Pathogen Profile.

Understand. Share. Make Informed Decisions.
Bad breath and gum irritation may be linked to changes in your oral microbiome. A simple saliva test detects and quantifies five targeted periodontal pathogens, providing quantitative microbial information you can share with your dental professional.
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DAILY ORAL PROBIOTIC FOR ORAL MICROBIOME SUPPORT

Supports Oral Wellness

Support Fresh Breath.

Supports Fresh Breath and Oral Wellness.
12 probiotic strains. 2 targeted prebiotics. Postbiotics from controlled fermentation. UniqueSmile™ supports your oral microbiome where it actually lives, not just on the surface.
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ADVANCED DAILY PROBIOTIC + DIGESTIVE SUPPORT

Daily Gut Wellness.

Naturally.

Complete Gut Wellness, Naturally.
17 probiotic strains. Digestive enzymes. CoQ-10. UniqueGut™ supports your microbiome from the inside out, delivered in an acid-resistant capsule built to survive the trip to your gut.
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CLIA-CERTIFIED LAB

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qPCR TECHNOLOGY

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RESULTS IN 2 BUSINESS DAYS

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COMPETITIVE PRICING

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SCIENCE-DRIVEN HEALTH INSIGHTS

Making complex science more meaningful for better health.

Unique Biosciences brings advanced testing technology and scientific insights together to support a deeper understanding of oral and overall health.

FOR DENTAL PROFESSIONALS

Bring Microbial Insights Into Your Practice.

Detect and quantify five periodontal pathogens with UniquePerioSignature™ saliva-based qPCR testing.

Quantitative Results
CLIA Certified Laboratory
Reports for Clinical Support
In-Office Saliva Test

FOR INDIVIDUALS

Understand Your Oral Microbiome.

Collect a saliva sample at home and discover insights into your oral health with our convenient Home Saliva Test.

Learn About Your Oral Health
Support Daily Oral Wellness
Explore Gut Health Solutions
Home Saliva Test
Science-Based Solutions
CLIA Certified Laboratory
Trusted by Dental Professionals
Supporting Oral & Gut Health

CLIA-CERTIFIED LABORATORY · MULTIPLEX qPCR

One Saliva Sample. Five Targeted Pathogens. Clearer Insights.

UniquePerioSignature™ uses multiplex qPCR technology to detect and quantify five targeted periodontal pathogens from a simple saliva sample. Results are available in as little as two business days.

UniquePerioSignature periodontal pathogen testing kit

The panel measures five targeted periodontal pathogens — Aa, Pg, Pi, Td, and Tf — to provide a quantitative microbial profile that can support clinical assessment and informed discussions with patients. Results should be considered alongside clinical findings and professional judgment.

  • Quantifies five targeted pathogens

    Aa, Pg, Pi, Td, and Tf

  • Results in as little as 2 business days

    Quantitative laboratory results to inform clinical discussions.

  • Multiplex qPCR technology

    Detects and quantifies multiple targeted pathogens in one test.

  • Supports clinical assessment

    Adds microbial data to the broader clinical picture.

Explore UniquePerioSignature™ For Dental Professionals

Complete Care for Your Smile, From the Inside Out.

Our advanced three-step protocol combines microbial testing with products designed to support oral and gut wellness and your overall health. 

Periodontal health starts with understanding your oral microbiome. The UniquePerioSignature™ Panel uses qPCR technology to identify and quantify 5 key oral pathogens in your saliva, providing clear microbial insights to support your dental assessment.

Once you understand your oral microbiome, take the next step in supporting it. UniqueSmile™ delivers 12 carefully selected probiotic strains with 25 billion CFU to help support a balanced oral microbiome and promote daily oral wellness.

UniqueGut™ is a comprehensive probiotic formula with 17 probiotic strains, 50 billion CFU, digestive enzymes, CoQ-10, prebiotics, and postbiotics to support digestive health, gut microbiome balance, and overall wellness.

Disclaimer: Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

Our Probiotic Solutions

Daily Support for a Healthier You

Explore our probiotic formulations for oral and digestive wellness.

Oral Health

UniqueSmile® Probiotics

A daily probiotic supplement formulated to support oral microbiome balance and fresh breath.

25 billion CFU

12 targeted probiotic strains

Convenient stick packs

30 individual servings

Supports oral health

Helps maintain a healthy oral microbiome

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Digestive Health

UniqueGut™ Probiotics

A comprehensive probiotic formulation to support digestive health and overall gut wellness.

17 probiotic strains

With targeted prebiotics and postbiotic components

Digestive enzymes and CoQ10

Additional components for daily support

Enteric-coated capsules

60 capsules per bottle

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FREE SHIPPING 

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FREE SHIPPING 

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FREE SHIPPING 

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Everything You Need At One Place.

From microbial testing to daily wellness support, an integrated oral health platform.

Direct-to-Consumer Periodontal Saliva Testing
14% Off
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Direct-to-Consumer Periodontal Saliva Testing

$99.00 USD $85.00 USD
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UniqueSmile® ProbioticsUniqueSmile® Probiotics
20% Off
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UniqueSmile® Probiotics

$29.90 USD $23.90 USD
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UniqueGut™ ProbioticsUniqueGut™ Probiotics
24% Off
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UniqueGut™ Probiotics

$32.90 USD $24.99 USD
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WHO WE ARE

The Mouth Knows More Than You Think.

Founded by scientists, physicians, dentists, and innovators. Unique Biosciences exists to close the gap between patients, providers, and diagnostics. We believe better health decisions begin with timely, meaningful information.

Our team works to turn complex science into thoughtful solutions that help people make more informed decisions.

We don't just run tests. We give people the answers they've been missing.
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